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Using DNA language models, it is simple to spot statistical trends in DNA sequences

Large language models (LLMs) are trained on a vast quantity of data and learn from statistical relationships between letters and words to anticipate what follows next in a phrase. For instance, the popular generative AI program ChatGPT’s LLM, GPT-4, is trained on many petabytes (several million gigabytes) of text.

By spotting statistical patterns in DNA sequences, biologists are using the power of these LLMs to reveal fresh insight into genetics. Similar to nucleotide language models, DNA language models are trained on a large number of DNA sequences.

The phrase “the language of life” as it relates to DNA is frequently used. A genome is a collection of DNA sequences that make up an organism’s genetic makeup. In contrast to written languages, the only letters in DNA are A, C, G, and T, which stand for the nucleoside adenine, cytosine, guanine, and thymine. Even though this genetic language appears straightforward, its grammar is still a mystery to us. DNA language models can help us better grasp genomic grammar one rule at a time.

Versatile Prediction

The capacity of ChatGPT to handle various jobs, from creating poetry to copy-editing an essay, gives it incredible strength. Models of DNA language are also flexible. Their uses include estimating the functions of various genomic regions and the interactions between multiple genes. Language models may also enable new analysis techniques by inferring genome properties from DNA sequences without requiring “reference genomes.”

For instance, a computer trained on the human genome was able to forecast the locations on RNA where proteins are most likely to interact. The “gene expression” process requires this interaction—transforming DNA into proteins. The amount of RNA translated into proteins is constrained by the binding of specific proteins to RNA. These proteins are thought to mediate gene expression in this manner. Because the form of the RNA is essential to these interactions, the model had to be able to predict where in the genome these interactions would occur and how the RNA would fold.

The ability of DNA language models to generate novel mutations in genomic sequences also enables researchers to forecast how these changes may occur. For instance, researchers used a language model at the genome size to forecast and retrace the evolution of the SARS-CoV-2 virus.

Distant Genomic Action

Biologists have recently realized that portions of the genome that were once thought of as “junk DNA” interact with other parts of the genome unexpectedly. A quick way to discover more about these concealed interactions is by using DNA language models. Language models can find relationships between genes in distant genome regions by spotting patterns over lengthy spans of DNA sequences.

Researchers from the University of California, Berkeley, offer a DNA language model with the capacity to learn the impacts of genome-wide variants in a recent preprint published on bioRxiv. These variations, single-letter alterations in the genome that cause illnesses or other physiological effects, are typically only discovered through pricy research investigations called genome-wide association studies.

It was trained using the genomes of seven species of plants from the mustard family and is known as the Genomic Pre-trained Network (GPN). Not only can GPN be modified to identify genome variations for any species, but it can also accurately name the various components of these mustard genomes.

Researchers created a DNA language model that could recognize gene-gene interactions from single-cell data in work just published in Nature Machine Intelligence. Understanding how genes interact at the single-cell level will provide fresh insights into illnesses with intricate pathways. This enables researchers to link genetic variables that drive disease development to variances between specific cells.

Hallucination into Creativity

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Google Cloud Introduces Generative Ai Support In Vertex Ai

Google is rolling out an update to its cloud-based machine learning platform, Vertex AI, which brings support for generative capabilities.

Enabling Access To Advanced Generative AI Models

Generative AI support on Vertex AI provides users access to Google’s extensive generative AI models.

These models cover various content types, including text and chat, images, code, and text embeddings.

Vertex AI allows you to select the one that best suits specific use cases by categorizing the models based on their content generation capabilities.

One of the notable generative AI models is PaLM 2, a language model that drives the PaLM API.

PaLM 2 boasts improved multilingual, reasoning, and coding capabilities, empowering users to tackle language-based tasks more efficiently and accurately.

Leveraging The Power Of PaLM API

Vertex AI enables users to leverage the generative capabilities of Google’s PaLM API.

This API, powered by large language models (LLMs), generates text and code in response to natural language prompts.

It offers specialized features tailored to different use cases, which include the following:

The PaLM API for text is fine-tuned to excel in language tasks.

The PaLM API for chat is designed for multi-turn conversations.

The Text Embedding API generates vector embeddings for input text.

The Codey APIs include models for code generation, code completion suggestions, and code-related questions.

Democratizing AI: Accessibility & Simplicity

By adding generative capabilities to Vertex AI, Google aims to democratize the technology by making it available to more people.

The platform offers an intuitive interface, including Generative AI Studio, that you can use without extensive technical knowledge.

Generative AI Studio focuses on low-code implementation. This means that Google’s multimodal foundation models, including PaLM, Imagen, Codey, and Chirp, can be integrated into applications with a few lines of code.

Developers, even those without a background in machine learning, can leverage this technology without worrying about the complexities of provisioning storage and compute resources.

Cost-Effectiveness & Flexibility

While using Vertex AI involves costs, Google Cloud offers various pricing options and flexibility to accommodate different user needs.

This ensures that individuals or small businesses with limited resources won’t have substantial upfront investments.

In Summary

Source: Google

Featured Image: Tada Images/Shutterstock

Meta’s Voicebox: The Ai That Speaks Every Language

In a groundbreaking development, Meta, the parent company of Facebook, has unveiled its latest generative artificial intelligence (AI) called Voicebox. Unlike traditional text-based AI models, Voicebox specializes in audio synthesis, allowing it to mimic speech patterns and generate natural-sounding audio clips. With the ability to read text in different languages and contribute to the immersive metaverse, Voicebox promises to revolutionize communication and accessibility. Let’s dive into the details of this innovative AI breakthrough.

Also Read: Meta Open-Sources AI Model Trained on Text, Image & Audio Simultaneously

The Evolution of Generative AI: From Text to Audio

Generative AI models like ChatGPT and Google’s Bard have long been capable of generating text-based responses using natural language processing and machine learning. However, Meta’s Voicebox takes the concept a step further by generating audio clips instead. This unique approach opens up exciting possibilities for enhanced communication and immersive experiences.

Also Read: An end-to-end Guide on Converting Text to Speech and Speech to Text

Voicebox: The Power of 2-Second Audio Samples

Voicebox, unveiled by Meta on Friday, introduces a novel technique for audio synthesis. Using just a 2-second audio sample, Voicebox can analyze and match the audio style, as well as generate text-to-speech or seamlessly recreate interrupted speech caused by external noise. This breakthrough technology aims to bridge gaps in communication and elevate the quality of audio interactions.

Breaking Language Barriers: Multilingual Capabilities

One of the most impressive features of Voicebox is its ability to read English text in various foreign languages. Whether it’s French, German, Spanish, Polish, or Portuguese, Voicebox can take an audio sample and transform it into natural-sounding speech in the desired language. This opens up new possibilities for global communication and language learning.

Enhancing the Metaverse: Voices that Bring Digital Worlds to Life

Meta envisions Voicebox as a powerful tool to enhance the metaverse, encompassing digital worlds where people gather to work, play, and socialize. By providing natural-sounding voices to virtual assistants and nonplayer characters (NPCs), Voicebox adds a layer of realism and immersion to these digital environments. Additionally, it has the potential to serve visually impaired individuals by enabling them to hear messages read in the familiar voices of their friends.

Also Read: Nvidia Introduces Tool to Build AI-Powered Life-Like Gaming Characters

Ethical Considerations: Balancing Authenticity and Potential Misuse

While Voicebox holds great promise, Meta acknowledges the need to address potential ethical concerns. The company is actively working on distinguishing between authentic speech and audio generated by Voicebox to prevent potential harm. Meta’s commitment to responsible AI development ensures that Voicebox will be deployed thoughtfully and with safeguards in place.

Also Read: EU Calls for Measures to Identify Deepfakes and AI Content

Our Say

Meta’s Voicebox AI represents a significant leap forward in audio synthesis and multilingual communication. By enabling natural-sounding speech in various languages and contributing to immersive digital environments, Voicebox has the potential to transform how we interact and experience the world. As Meta continues refining this innovative AI technology, it is crucial to balance pushing boundaries and ensuring responsible use. With Voicebox, the future of communication is set to become more inclusive, accessible, and captivating than ever before.

Learn More: Unlock the boundless world of Generative AI and learn more about such innovative technologies at our upcoming workshop at the DataHack Summit 2023.


12 Common Mistakes With Customer Analytical Models

Optimise your customer analytics by getting the models right

Customer analytical models can deliver huge value for companies that invest in them to improve their sales and marketing activities. But even well-known big brands can get it wrong when designing, implementing and operating these models. From Barclays to John Lewis, Cineworld to Pizza Express, businesses across all sectors are benefiting from the use of customer analytics. These days, it is unusual to find a company that does not analyse customer data, even in its simplest form. Customer analytics may fall under business intelligence, marketing operations, finance or even customer support, but wherever it lies it will have the potential to improve the optimisation of sales and marketing functions.

Companies often want to know which products or services specific customers are most likely to purchase, which customers need a nudge to help them to complete a sale and which customers are most likely to leave them. When used intelligently the results that customer analytical models generate have a direct and quantifiable impact on the revenue and profitability of a company. Given this, one would expect that the development and operation of customer analytics would be second-nature to businesses, and a well-established methodology. At Intilery however we often find that companies have little or no use of analytical models within their sales and marketing functions. In addition, where models have been implemented, common mistakes are evident.

Areas for focus

Typically, there are three areas which need the most attention (not accounting for having no model at all).

The planning, design and definition of the models.

The deployment and operation of the models.

The refinement and lifecycle of the models.

We’ll look at the mistakes I see across these three areas:

1. Setting the wrong customer value

The second most utilised customer analytics model is the one most often designed incorrectly. The most common design flaw in the definition of the retention model is the valuation of the customer (sometimes referred to as CLV – Customer Lifetime Value). Consultants often encounter CLV definitions that do not represent true lifetime value, rather a current or recent customer valuation.

Utilising the value attributed to a customer, a retention model may assign a deep discount or a margin-heavy offer to a customer who has only recently become a high-value customer and is likely to churn (either churn completely by leaving or churn to a lower value-level).

Conversely the retention model attributed via the customer value may offer too shallow an offer or incentive to customers likely to churn who were previously high-value customers.

“The retention model should look at the value the customer has previously generated for the company and provide appropriate offers/incentives to the customer to either bring them back to their historically high level of value or stop them churning.” The problem is that by looking at

The problem is that by looking at recent activity or overly averaged values, the wrong or inappropriate offers and incentives may be applied to the customer. Instead, the retention model should look at the value the customer has previously generated for the company and provide appropriate offers or incentives to the customer, either to bring them back to their historically high level of value or prevent them from churning.

2. Not utilising customer value propensity

The second issue with valuing a customer for retention is not taking into account the customers’ propensity to increase/decrease in value, by only looking at current value and/or past value. If this is the case, you limit your model to events that have happened and not events that could happen. 3. Ignoring the social value of a customer The third issue with retention modeling is not taking into account the social network value of the customer. If a customer leaves, or does not receive the service or incentives they expect (yes some customers do expect incentives), then the customer may broadcast this on their social network. Taking into account a customer with a very well connected (virtual or physical) network, you may wish to increase the value of a customer and incentivise accordingly for retention.

3. Not retaining customers all of the time

Another issue with retention modeling is that they are often only run at the beginning of the month to identify customers likely to churn within that month (or any other given period).

To be effective the retention model needs to operate in real-time identifying customers and visitors that are likely to churn and applying the required action to prevent it. Churn triggers are used to identify customers that are most likely to churn. These could include; a product being out of stock, a late delivery, a slow loading page, very few (or no) search results or simply gesturing to leave the page.

For a retention model to be effective, the model must include periodic (daily, weekly or monthly) analysis of churn detection along with real-time churn-triggers. Using these together it is possible to apply offers/incentives or other actions to retain customers and more importantly do so in a cost-effective and margin protecting way.

4. Ignoring seasonal variations

Another common error is developing a retention model that doesn’t take into account seasonal variations, or using a single retention model all year. Customers behave differently according to the season and according to seasonal habits. An obvious example is the increase in browse or spend at Christmas, but what about other calendar events? All variations should be accounted for. Also, products and services may have seasonal variations – such as buying cycles or budgets – and companies may have unforeseen variations due to unpredictable trends.

Whatever the seasonal variation, retention models should be careful to incorporate these into the design.

Segmentation Models 5. Lack of granularity

Segmentation models are the most implemented model across all companies and industries, and yet often the least used. Typically, this model will only place customers into high-level segments and built around value, product, basic behavioural data and sometimes geo-demographic segmentation. The issue with this approach, whilst valuable, is that it does not empower companies to deliver ongoing actions. Instead, it drives businesses to shape themselves around the customer segments and shape their offerings for them. For example; a company discovers it has a noticeable percentage of older customers and therefore develops specific services/products for that customer segment.

The issue with high-level segmentation is that it doesn’t take into account the detailed segments, where segments may contain a small number of customers or even a segment of one customer (known as one-to-one marketing). Detailed segmentation allows a company to take action (often in an automated way) on the various individual behaviours of its customers. The results of of this type of segmentation are much more useful and clear. For example, a detailed segment in the travel industry could show how each specific customer behaves; the number of searches before booking, the prominent day of the week for engagement, the seasonal variation in browsing behaviour, the likelihood that a customer “surfs for vouchers” before completing or a change in the type of service/product the customer views/purchases.

Examining customers across detailed segments enables companies to take specific actions to change or influence behaviours, such as, targeting customers with offers when they are most likely to be receptive or delivering an upsell incentive for a customer who has dropped down to a lower than usual price-point. The key learning is that by deploying detailed segmentation it is possible to target specific actions rather than shape your company around a few high-level customer segments.

Channel Migration Models 6. Migrating customers for the wrong Reason

Companies often devise methods to migrate customers from one channel to another, for both marketing/sales communications and for customer services (sales and service). The mistake here is to do this for the wrong reason or at the wrong time. Companies will try and lower the cost of managing a customer by migrating them from a higher-cost channel to a lower-cost channel, the operational cost for managing customers may be reduced, but this could greatly reduce the lifetime value of the customer if the migrated channel is not sufficiently sales focused. Also a company may migrate customers from social to email, or from branch to online-chat. Again the operational cost of communications may be reduced but not taking into account the sales effectiveness of the new channel could result in lost sales.

Activity Optimisation Models 7. Selling instead of helping

Companies can model the lifecycle of a customer at an engagement level to ensure that each customer has their particular needs met, though often a company will only look at the sales category of actions to try and sell the next product or service to them. While this model is useful and can be used to forecast revenue, it fails to capture the bigger picture.

The next action a customer needs is dependent on many individual and personal factors. Companies should design a number of actions that can be applied (with personalisation) to satisfy the customer and promote customer loyalty. More worryingly, only looking at the sales channel and bombarding customers with constant messaging about products or services they can buy could actually disengage customers completely. Intilery recently worked with a client that had succesfully increased sales in the short-term but had not been able to see the long-term damage it was doing to customer loyalty and retention.

“A well designed model will take into account all possible needs of a customer and communicate solutions to the customer at the right time”.

For example: –

Informing a customer about the company’s app and its benefits

Tell the customer about different ways they can get in touch

Provide details of other channel services, e.g. physical store location or opening hours

Collect further personal details or preferences (but clearly explain why)

Ask the customer for a referral (perhaps with incentives)

Show the customer how to share their purchase/booking to help validate purchasing decisions Know when NOT to communicate with a customer (for a period of time)

Strategic Mistakes 8. Working in silos

Another common mistake is not gaining adequate internal support or buy-in from across the business. Stakeholders from all areas of the business should be involved with the design and operation of a customer analytics model. We recommend that when planning this type of model that you use a RACI matrix for identifying and involving stakeholders.

Why involve other areas of the business?

Ask yourself:-

Can the business operationally support outputs and actions of the model?

Will there be operational costs that need to be budgeted for?

Will customer support need to implement new policies and practices?

Does marketing need to work with new key messages?

Will sales need to adjust revenue targets?

Do new KPIs need to be setup to ensure the model has buy-in longevity?

9. Treating new customers like everyone else

New customers must be treated very carefully, they top-up the customer base and directly impact churn levels. A new customer is the most receptive to offers and cross-sell, but is also the most likely to churn. Reasons for failure are often categorised as too much or alternatively incorrect engagement. Getting this right is key to a long-lasting and profitable relationship with customers. One approach is to simply not contact new customers for a period of time as the behavioural profiles of new customers does not usually reflect their long-term behavior. While this will improve the churn rate of new customers it will affect the bottom line. Instead, a better approach is to design a welcome programme that utilises next-action analysis, detailed segmentation and of course seasonal variation.

The actions that are taken for new customers should be unique and personalised to every individual customer, this may mean that for certain new customers no contact is made at all, for others a full suite of engagement activity, website personalisation, offers and cross-sells are applied.

10. Not refreshing models

As part of ongoing operations, a typical mistake is not refreshing the customer analytical models. Few companies revisit and analyse the ongoing effectiveness of their customer models. Failure to do so depletes the effectiveness and efficiency of the models and can lead to less profitability and increased churn.

As time passes, the ability to gauge the effectiveness of the analytical models increases, therefore companies should regularly assess their models. A variety of assumptions will have been made following the design and deployment of models, when it was simply not possible to analyse or predict the outcomes or understand the customer environment. Taking the time to periodically review your models will allow you to test your assumptions against new real-world data.

Also important is the changing landscape of the business, as company strategies, operations and marketing activities change, the structure, desired outcomes and operations of the analytical models may also require updating. Taking the time to update these to match the direction of the company will ensure strategic alignment.

11. Testing the wrong way

This is commonly caused by uncontrollable environmental factors or over reaching on causation/correlation. The most effective way to test customer analytical models is to test them over a number of business periods, whilst applying statistical methods, and finally simply asking the question “does this make sense”.

Instacart Revolutionizes Shopping With Ai

In a groundbreaking move, Instacart has announced the launch of its new AI search tool, “Ask Instacart,” powered by OpenAI‘s ChatGPT. This innovative feature aims to enhance the shopping experience for customers by providing personalized recommendations and assisting with shopping inquiries. With the new tool embedded in the Instacart app, users can save time and experience shopping like never before. Customers can receive valuable information about products, food preparation, dietary considerations, and more. Let’s explore how Instacart’s AI-powered search will transform how we shop.

Introducing “Ask Instacart”: Your Personal Shopping Assistant

Instacart’s latest innovation, “Ask Instacart,” is an AI-powered search tool that streamlines the shopping process & offers personalized assistance to customers. By leveraging the capabilities of ChatGPT, Instacart aims to provide relevant recommendations and answer a wide range of shopping-related questions.

Also Read: Amazon to Make ‘Once-in-a Generation’ Change With AI Search

A Smarter Shopping Experience: How “Ask Instacart” Works

The new AI search experience is seamlessly integrated into the Instacart app’s search bar, empowering users to seek information and guidance on various food-related queries. From recipe suggestions and dietary considerations to product attributes and food pairing ideas, “Ask Instacart” acts as a virtual shopping assistant at users’ fingertips.

Empowering Customers with Personalized Recommendations

With “Ask Instacart,” customers can receive personalized recommendations tailored to their unique needs. The AI-powered tool delivers timely and relevant suggestions to make meal planning a breeze. It can suggest suitable side dishes for lamb chops, alternative fish options to salmon, or dairy-free snacks for kids.

A Multifaceted Solution for Food Questions

Instacart understands the complexity of answering food-related queries, which is why “Ask Instacart” aims to cover a wide array of topics. From budget considerations and dietary specifications to cooking skills and personal preferences, the AI search tool offers comprehensive support in answering customers’ food questions and guiding them toward the perfect meal.

Streamlining the Shopping Experience: Instacart as a One-Stop Shop

With the introduction of “Ask Instacart,” the app evolves into a comprehensive platform, eliminating the need for users to search for recommendations on external media. Instacart becomes a one-stop shop, allowing customers to directly enter their queries within the app and receive tailored responses, simplifying the shopping process and saving valuable time.

Building on the Success: Instacart’s Commitment to AI

The launch of “Ask Instacart” follows Instacart’s previous integration of ChatGPT with its plug-in. The added feature enabled users to express their food needs in natural language. Instacart recognizes the potential of generative-AI technology and continues to leverage its capabilities to provide a seamless & efficient shopping experience.

Focused Expertise: The Specialization of “Ask Instacart”

Instacart acknowledges that generative AI technology is still in its early stages. Therefore, “Ask Instacart” is a specialized model designed specifically to respond to relevant food-related questions. By focusing on the domain of food and culinary expertise, Instacart ensures accurate and valuable responses to customer inquiries.

Our Say

Instacart’s launch of the AI-powered search tool, “Ask Instacart,” marks a significant step forward in revolutionizing the shopping experience. By leveraging the capabilities of OpenAI’s ChatGPT, Instacart empowers customers with personalized recommendations and expert guidance, transforming its app into a comprehensive platform for all their food-related needs. With “Ask Instacart,” shopping for ingredients and planning meals becomes seamless and efficient, saving time and enhancing customer satisfaction.


Calibration Of Machine Learning Models

This article was published as a part of the Data Science Blogathon.


source: iPhone Weather App

A screen image related to a weather forecast must be a familiar picture to most of us. The AI Model predicting the expected weather predicts a 40% chance of rain today, a 50% chance of Wednesday, and a 50% on Thursday. Here the AI/ML Model is talking about the probability of occurrence, which is the interesting part. Now, the question is this AI/ML model trustworthy?

As learners of Data Science/Machine Learning, we would have walked through stages where we build various supervisory ML Models(both classification and regression models). We also look at different model parameters that tell us how well the model performs. One important but probably not so well-understood model reliability parameter is Model Calibration. The calibration tells us how much we can trust a model prediction. This article explores the basics of model calibration and its relevancy in the MLOps cycle. Even though Model Calibration applies to regression models as well, we will exclusively look at classification examples to get a grasp on the basics.

The Need for Model Calibration

Wikipedia amplifies calibration as ” In measurement technology and metrology, calibration is the comparison of measurement values delivered by a device under test with those of a calibration standard of known accuracy. “

The model outputs two important pieces of information in a typical classification ML model. One is the predicted class label (for example, classification as spam or not spam emails), and the other is the predicted probability. In binary classification, the sci-kit learn library gives a method called the model.predict_proba(test_data) that gives us the probability for the target to be 0 and 1 in an array form.  A model predicting rain can give us a 40% probability of rain and a 60% probability of no rain. We are interested in the uncertainty in the estimate of a classifier. There are typical use cases where the predicted probability of the model is very much of interest to us, such as weather models, fraud detection models, customer churn models, etc. For example, we may be interested in answering the question, what is the probability of this customer repaying the loan?

Let’s say we have an ML model which predicts whether a patient has cancer-based on certain features. The model predicts a particular patient does not have cancer (Good, a happy scenario!).  But if the predicted probability is 40%, then the Doctor may like to conduct some more tests for a certain conclusion. This is a typical scenario where the prediction probability is critical and of immense interest to us. The Model Calibration helps us improve the model’s prediction probability so that the model’s reliability improves. It also helps us to decipher the predicted probability observed from the model predictions. We can’t take for granted that the model is twice as confident when giving a predicted probability of 0.8 against a figure of 0.4.

We also must understand that calibration differs from the model’s accuracy. The model accuracy is defined as the number of correct predictions divided by the total number of predictions made by the model. It is to be clearly understood that we can have an accurate but not calibrated model and vice versa.

If we have a model predicting rain with 80% predicted probability at all times, then if we take data for 100 days and find 80 days are rainy, we can say that model is well calibrated. In other words, calibration attempts to remove bias in the predicted probability.

Consider a scenario where the ML model predicts whether the user who is making a purchase on an e-commerce website will buy another associated item or not. The model predicts the user has a probability of 68% for buying Item A  and an item B probability of 73%. Here we will present Item B to the user(higher predicted probability), and we are not interested in actual figures. In this scenario, we may not insist on strict calibration as it is not so critical to the application.

The following shows details of 3 classifiers (assume that models predict whether an image is a dog image or not). Which of the following model is calibrated and hence reliable?

(a) Model 1 : 90% Accuracy, 0.85 confidence in each prediction

(b) Model 2 : 90% Accuracy, 0.98 confidence in each prediction

(c) Model 3 : 90% Accuracy ,0.91 confidence in each prediction

If we look at the first model, it is underconfident in its prediction, whereas model 2 seems overconfident. Model  3 seems well-calibrated, giving us confidence in the model’s ability. Model 3 thinks it is correct 91% of the time and 90% of the time, which shows good calibration.

Reliability Curves

The model’s calibration can be checked by creating a calibration plot or Reliability Plot. The calibration plot reveals the disparity between the probability predicted by the model and the true class probabilities in the data. If the model is well calibrated, we expect to see a straight line at 45 degrees from the origin (indicative that estimated probability is always the same as empirical probability ).

We will attempt to understand the calibration plot using a toy dataset to concretize our understanding of the subject.

Source: own-document

The resulting probability is divided into multiple bins representing possible ranges of outcomes. For example,  [0-0.1), [0.1-0.2), etc., can be created with 10 bins. For each bin, we calculate the percentage of positive samples. For a well-calibrated model, we expect the percentage to correspond to the bin center. If we take the bin with the interval [0.9-1.0), the bin center is 0.95, and for a well-calibrated model, we expect the percentage of positive samples ( samples with label 1) to be 95%.

Source: self-document

We can plot the Mean predicted value (midpoint of the bin ) vs. Fraction of TRUE Positives in each bin in a line plot to check the calibration. of the model.

We can see the difference between the ideal curve and the actual curve, indicating the need for our model to be calibrated. Suppose the points obtained are below the diagonal. In that case, it indicates that the model has overestimated (model predicted probabilities are too high). If the points are above the diagonal, it can be estimated that model has been underconfident in its predictions(the probability is too small). Let’s also look at a real-life Random Forest Model curve in the image below.

If we look at the above plot, the S curve ( remember the sigmoid curve seen in Logistic Regression !) is observed commonly for some models. The Model is seen to be underconfident at high probabilities and overconfident when predicting low probabilities. For the above curve, for the samples for which the model predicted probability is 30%, the actual value is only 10%. So the Model was overestimating at low probabilities.

The toy dataset we have shown above is for understanding, and in reality, the choice of bin size is dependent on the amount of data we have, and we would like to have enough points in each bin such that the standard error on the mean of each bin is small.

Brier Score

We do not need to go for the visual information to estimate the Model calibration. The calibration can be measured using the Brier Score. The Brier score is similar to the Mean Squared Error but used slightly in a different context. It takes values from 0 to 1, with 0 meaning perfect calibration, and the lower the Brier Score, the better the model calibration.

The Brier score is a statistical metric used to measure probabilistic forecasts’ accuracy. It is mostly used for binary classification.

Let’s say a probabilistic model predicts a 90% chance of rain on a particular day, and it indeed rains on that day. The Brier score can be calculated using the following formula,

Brier Score = (forecast-outcome)2

 Brier Score in the above case is calculated to be (0.90-1)2  = 0.01.

The Brier Score for a set of observations is the average of individual Brier Scores.

On the other hand, if a model predicts with a 97%  probability that it will rain but does not rain, then the calculated Brier Score, in this case, will be,

Brier Score = (0.97-0)2 = 0.9409 . A lower Brier Score is preferable.

Calibration Process

Now, let’s try and get a glimpse of how the calibration process works without getting into too many details.

Some algorithms, like Logistic Regression, show good inherent calibration standards, and these models may not require calibration. On the other hand, models like SVM, Decision Trees, etc., may benefit from calibration.  The calibration is a rescaling process after a model has made the predictions.

 There are two popular methods for calibrating probabilities of ML models, viz,

(a) Platt Scaling

(b) Isotonic Regression

It is not the intention of this article to get into details of the mathematics behind the implementation of the above approaches. However, let’s look at both methods from a ringside perspective.

The Platt Scaling is used for small datasets with a reliability curve in the sigmoid shape. It can be loosely understood as putting a sigmoid curve on top of the calibration plot to modify the predictive probabilities of the model.

The above images show how imposing a Platt calibrator curve on the reliability curve of the model modifies the curve. It is seen that the points in the calibration curve are pulled toward the ideal line (dotted line) during the calibration process.

It is noted that for practical implementation during model development, standard libraries like sklearn support easy model calibration(sklearn.calibration.CalibratedClassifier).

Impact on Performance

It is pertinent to note that calibration modifies the outputs of trained ML models. It could be possible that calibration also affects the model’s accuracy. Post calibration, some values close to the decision boundary (say 50% for binary classification) may be modified in such a way as to produce an output label different from prior calibration. The impact on accuracy is rarely huge, and it is important to note that calibration improves the reliability of the ML model.


In this article, we have looked at the theoretical background of Model Calibration. Calibration of Machine Learning models is an important but often overlooked aspect of developing a reliable model. The following are key takeaways from our learnings:-

(a) Model Calibration gives insight or understanding of uncertainty in the prediction of the model and in turn, the reliability of the model to be understood by the end-user, especially in critical applications.

(b) Model calibration is extremely valuable to us in cases where predicted probability is of interest.

(c) Reliability curves and Brier Score gives us an estimate of the calibration levels of the model.

(c) Platt scaling and Isotonic Regression is popular methods to scale the calibration levels and improve the predicted probability.

Where do we go from here? This article aims to give you a basic understanding of Model Calibration. We can further build on this by exploring actual implementation using standard python libraries like scikit Learn for use cases.

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